Adverse Childhood Experiences (ACEs) are stressful experiences that happen before the age of 18. They fall under three categories: abuse, neglect, household challenges. ACEs have been linked to premature death as well as to various health conditions, including those of mental disorders.
Toxic stress linked to childhood maltreatment is related to a number of neurological changes in the structure of the brain and its function. The Adverse Childhood Experiences Study, published in 1998, was the first large scale study to look at the relationship between ten categories of adversity in childhood and health outcomes in adulthood.